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Zielstruktur für maßgeschneiderte Fungizide | Chemikalien.de
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Zielstruktur für maßgeschneiderte Fungizide

August 9, 2002 by admin 

Frankfurter Max-Planck-Wissenschaftler enthüllen molekulare Architektur und
Wirkungsweise einer für Pilze und Hefen typischen Protonenpumpe.Proteine, die
Ionen und andere Stoffe durch die Außenmembran der Zelle transportieren, gehören
zur Grundausstattung aller Organismen. Durch Vergleich mit der Struktur einer
Kalzium-Pumpe haben Wissenschaftler am Max-Planck-Institut für Biophysik in
Frankfurt die Struktur und den Regulationsmechanismus der Protonenpumpe in einer
Hefe aufgeklärt Science Express, 8. August 2002. Der Regulationsmechanismus
bildet einen potentiellen Angriffspunkt für neue Fungizide.

Homologie-Modell der Protonenpumpe (farbiges Band) nach Einpassen
in die elektronenmikroskopisch bestimmte Dichtekarte (blaues Netz). Bild: Max-Planck-Institut
für Biophysik

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